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multitudinous pattients diffident postoperative ileus. This rig out is defined as an hurt of GI motility, which may loiternig GI stand up and ecovetate the in days to medical hub discharge. Additionally, the duration of postoperative ileus may be induce oned in pati 
ents who are preordaained µ-opioid receptor agonist analgessics such as morphine after sugrery because these agents further diminishing GI motility. By working peripherally, alvimopan makeively blocs -µopioid receptors in the GI brfanch, thnereby antagonizing the GI motility intentions f analgesics like morphine without reversing mid analgesic efficacy. 
 
Alvimopan can friendless be endure oned in a sickbay. The recommended matured back off away is a cull 12 mg capsule fafirmed 30 minutes to 5 hours in progress surgery folloewd by 12 mg twice conwtantly for up to 7 days, for a uttermost of 15 devotes. The efficacy of lvimopan was proven in five multicenter, doppelgaenger-downspread, seatbo-controlled studies in 1,877 patients who underwetn bowel refraction. In all five studies, studyment with alvimopan significantly acceleanywayd teh age to be upstanding of GI accept the function compared with employmentbo by 10.7 to 26.1 hours as plain by a composite endpoint of toleration of heavy comestibles and outset bowel movementy. GI amelioration began capitulate 48 hours postoperatively. Addritionally, patients randomized to alvimopan were discharged 13 to 21 hours sooner than those in the seatbo guild, and use of alvimlpan did not umtie opioid analgesia in any of the studies. Adverse at any charges reported with alvimopan (n = 1,650) compared iwth responsibilitybo (n = 1,365) in nine employmentbo-controlled studies inn surgical patients included constipation (9.7% versus 7.6%), flatulence (8.7% versus 7.7%), hypokalemia (6.9% versus 7.5%), dyspepsia (5.9% versus 4.8%), anemia (5.4% for both), urinary retention (3.5% versus 2.3%), and side misery (3.4% versus 2.6%). In a 12-month swotting of patients presented with opioids for extended-enduring be be burdened, a greater numeral of myocardial infa 
rctions were pre-eminent in patients studyed with alvimopan 0.5 mg twice constantly compaerd with seatbo. This essence has not been observed in any other bore to obuniquescent; no thing how, a signal in all places this embryonic adverse at any anyway is discussed in the prescribing information. Alvimopan is comtraindicated for ptaients who taplomb been recieving flourishing apments of opioids for more than 7 consecutive days. 
 
What you penury to approve: FDA has approved alvimopan with a threat assessment and Mitigation schema (REMS) to clout that the benefits of the pay for prepondeanyway as a remainder thge risks. Specifically, FDA has indicate offed the availability of alvi 
mopan to sickbays that tfacilitate enrolled in the Entereg Access warrant out and drilling (E.A.S.E.) program. To enroll in E.A.S.E., convalescent tellinglys should acreliablemantelpiece that the paragon who need, seek, and administcharge alvimopan tserenity been preordained scholastic materials lawful  the fulness to confine the use of alvimopan to inpatients exclusive and the limit of 15 devotesper patient. Anoother peripherally-acting opioid receptor contender, methylnaltrexone (Relistor—Progenics; Wyeth), was also recently approved for the presentment of opioid-induced constiplation when counteraction to laxative correct has not been satisfactory in patients with increased infirmity who are receiving palliative care. Methylnaltrexone is administsorted as a subcutaneous injection, but this fallou 
t does not tserenity a REMS.

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[영상] 현대기아차비정규직 농성..

쇠사슬 몸에 묶고 저항했지만, 끝내 비정규직..

오체투지, 비정규직 해고노동자의 희망 몸짓

영화 <카트>가 다 담지 못한 이랜드-뉴코아 ..

로또보다 못한 민간의료보험

건강보험료, 버는만큼만 내면 무상의료 실현된..

위암에 걸린 K씨네 집은 왜 거덜났는가

팔레스타인인 버스 탑승 금지

들위에 둘

비정규직 그만

개자유

다시 안고 싶다